' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
8.3
USERS' SCORE
Very Good
Based on 14 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-12 (as Cyanocobalamin)
2,500 mcg
104,167%
Top Medical Research Studies
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Study focuses on isolated treatment
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
Read More
9
Vitamin B12 reverses back pain
Progressive Decrease in Function and Ambulation Potential: A Case of Subacute Combined Degeneration.
Moderate relevance to back pain
We explored the effects of vitamin B12 treatment on a patient experiencing severe back pain, along with other symptoms associated with subacute combined degeneration (SCD) from prolonged vitamin B12 deficiency. This case involved a 49-year-old man who faced a year of worsening weakness, pain, and gait abnormalities.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Read More
7
Methylcobalamin shows pain relief potential
Methylcobalamin: a potential vitamin of pain killer.
Moderately relevant findings
We explored the potential effects of methylcobalamin, an activated form of vitamin B12, in alleviating back pain. In recent studies, this vitamin has shown promise in treating various pain conditions, including diabetic neuropathy and low back pain.
Our observations highlighted that methylcobalamin may contribute to pain relief by enhancing nerve regeneration and improving nerve conduction. Additionally, it appears to decrease ectopic discharges in sensory neurons, which could be linked to pain sensitivity.
While the findings suggest that methylcobalamin may be effective in reducing back pain, we noted that it is not clear whether the vitamin was studied as a standalone treatment. This aspect slightly limits our understanding of its true efficacy. Overall, the potential analgesic properties of methylcobalamin present an interesting area for further research and consideration in pain management strategies.
Our observations highlighted that methylcobalamin may contribute to pain relief by enhancing nerve regeneration and improving nerve conduction. Additionally, it appears to decrease ectopic discharges in sensory neurons, which could be linked to pain sensitivity.
While the findings suggest that methylcobalamin may be effective in reducing back pain, we noted that it is not clear whether the vitamin was studied as a standalone treatment. This aspect slightly limits our understanding of its true efficacy. Overall, the potential analgesic properties of methylcobalamin present an interesting area for further research and consideration in pain management strategies.
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Most Useful Reviews
9
Nervous system support
Vitamin B12 is essential for the nervous system, aiding myelin synthesis and enhancing signal transmission. After taking it, I felt a surge of energy and vitality, my endurance improved, and I experienced no illnesses or hair loss. It helps keep homocysteine levels in check, protects blood vessel walls, and supports cardiovascular health, which is crucial for alleviating back pain.
Read More
9.5
Anemia treatment
I bought this due to severe anaemia. Switching from 1500mcg to 2500mcg worked wonders, as a blood test confirmed my anaemia was cured. I also suggested it to my aunt for her neuralgia, and she noted a reduction in her back pain!
Read More
8.8
Numbness improvement
I began taking B12 as prescribed for my back pain, and after a week, I noticed an improvement in the numbness in my limbs. The pleasant taste makes it easy to take, and I recommend it for anyone experiencing back pain.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
8.3
9.5
Mannitol and vitamin B12 improve PS
Effect of Mannitol plus Vitamins B in the management of patients with piriformis syndrome.
Combination may obscure B12 effects.
We investigated the impact of a treatment combining mannitol and vitamin B on piriformis syndrome (PS), which is characterized by sciatic nerve entrapment. In a study involving 22 patients, participants received a five-day intravenous infusion of mannitol alongside a six-week regimen of vitamin B, including B1, B2, and B12.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Read More
9
Dexamethasone and B12 improve recovery
Effects of dexamethasone combined with vitamin B12 on percutaneous endoscopic interlaminar discectomy early outcomes: a randomized controlled trial.
Vitamin B12 effects are combined
We explored the effects of combining dexamethasone with vitamin B12 during epidural injections in patients undergoing a specific type of spinal surgery, known as percutaneous endoscopic interlaminar discectomy (PEID). This study aimed to determine whether this combination could alleviate low back and leg pain that often lingers after the surgery. Patients were randomly assigned to two groups: one received only the surgery (the single surgery group), while the other received the surgery along with the combined treatment of medication.
We found that patients who received the combination of dexamethasone and vitamin B12 experienced a notable reduction in early postoperative pain, which we measured using various scoring systems. Additionally, the injections appeared to decrease the levels of certain inflammatory factors in the body, suggesting a potential biological mechanism behind the relief they experienced. Early recovery metrics, like hospital stay duration and overall satisfaction, were also improved in those receiving the combined treatment.
Therefore, the results encourage considering the use of vitamin B12 along with dexamethasone for patients recovering from disc surgery, as it seems to enhance their recovery experience effectively.
We found that patients who received the combination of dexamethasone and vitamin B12 experienced a notable reduction in early postoperative pain, which we measured using various scoring systems. Additionally, the injections appeared to decrease the levels of certain inflammatory factors in the body, suggesting a potential biological mechanism behind the relief they experienced. Early recovery metrics, like hospital stay duration and overall satisfaction, were also improved in those receiving the combined treatment.
Therefore, the results encourage considering the use of vitamin B12 along with dexamethasone for patients recovering from disc surgery, as it seems to enhance their recovery experience effectively.
Read More
9
Vitamin B12 reverses back pain
Progressive Decrease in Function and Ambulation Potential: A Case of Subacute Combined Degeneration.
Moderate relevance to back pain
We explored the effects of vitamin B12 treatment on a patient experiencing severe back pain, along with other symptoms associated with subacute combined degeneration (SCD) from prolonged vitamin B12 deficiency. This case involved a 49-year-old man who faced a year of worsening weakness, pain, and gait abnormalities.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Read More
9
Gelatin sponge aids postoperative recovery
Cocktail Treatment with a Gelatin Sponge Impregnated with Ropivacaine, Dexamethasone, and Vitamin B12 Promotes Early Postoperative Recovery after Percutaneous Endoscopic Lumbar Discectomy: A Retrospective, Case-Controlled Study.
Vitamin B12's effects are unclear
We conducted a study to understand if a "cocktail treatment," which includes a gelatin sponge soaked in ropivacaine, dexamethasone, and vitamin B12, could improve recovery after a procedure known as percutaneous endoscopic lumbar discectomy (PELD). This treatment aimed to address not just the mechanical issues of a herniated disc but also the inflammatory responses that often lead to prolonged pain.
Our research involved 100 patients who underwent PELD for single-level lumbar disc herniation. Half of them received the cocktail treatment, while the other half were given a gelatin sponge without any medication as a control group. We evaluated the outcomes based on pain relief and functional recovery, using tools like the Visual Analog Scale (VAS) for assessing back and leg pain and the Oswestry Disability Index (ODI) for measuring disability.
The inclusion of vitamin B12 in the cocktail treatment seems to promote earlier pain relief and functional recovery after surgery. However, because this treatment was mixed with other medications, it’s hard to isolate the specific effect of vitamin B12 on its own. While we saw positive results in terms of overall recovery, we can't definitively claim that vitamin B12 alone contributed significantly to alleviating back pain.
Our research involved 100 patients who underwent PELD for single-level lumbar disc herniation. Half of them received the cocktail treatment, while the other half were given a gelatin sponge without any medication as a control group. We evaluated the outcomes based on pain relief and functional recovery, using tools like the Visual Analog Scale (VAS) for assessing back and leg pain and the Oswestry Disability Index (ODI) for measuring disability.
The inclusion of vitamin B12 in the cocktail treatment seems to promote earlier pain relief and functional recovery after surgery. However, because this treatment was mixed with other medications, it’s hard to isolate the specific effect of vitamin B12 on its own. While we saw positive results in terms of overall recovery, we can't definitively claim that vitamin B12 alone contributed significantly to alleviating back pain.
Read More
9
Vitamin B12 aids back pain relief
Treatment of acute, non-traumatic pain using a combination of diclofenac-cholestyramine, uridine triphosphate, cytidine monophosphate, and hydroxycobalamin.
Lower relevance score rationale
We conducted a thorough investigation into how vitamin B12, alongside a combination of other treatments, impacts pain relief in individuals suffering from back pain. Our focus was on a clinical study that compared two groups: one receiving a combination of diclofenac-cholestyramine, uridine, cytidine, and vitamin B12, while the other group received only the nucleotides and vitamin B12.
After a 10-day treatment period, we observed that the combination including vitamin B12 led to a significant reduction in pain for a large number of participants. Specifically, about 87.5% of those in the combined treatment group experienced a notable reduction in pain measured by the Visual Analog Scale (VAS). In contrast, only 51.23% of the control group reported similar results.
Additionally, we found that 80% of participants receiving the combination treatment experienced a marked improvement in their daily functionality. This was a stark contrast to just 29.3% in the control group, showcasing the potential benefits of adding vitamin B12 to pain management regimens in treating acute, non-traumatic back pain.
Importantly, we noted that the overall safety profile of the treatments was good, with not many adverse effects reported. This suggests that incorporating vitamin B12 with other active ingredients can be a well-tolerated option for those dealing with painful conditions affecting the lower back, hips, and neck.
After a 10-day treatment period, we observed that the combination including vitamin B12 led to a significant reduction in pain for a large number of participants. Specifically, about 87.5% of those in the combined treatment group experienced a notable reduction in pain measured by the Visual Analog Scale (VAS). In contrast, only 51.23% of the control group reported similar results.
Additionally, we found that 80% of participants receiving the combination treatment experienced a marked improvement in their daily functionality. This was a stark contrast to just 29.3% in the control group, showcasing the potential benefits of adding vitamin B12 to pain management regimens in treating acute, non-traumatic back pain.
Importantly, we noted that the overall safety profile of the treatments was good, with not many adverse effects reported. This suggests that incorporating vitamin B12 with other active ingredients can be a well-tolerated option for those dealing with painful conditions affecting the lower back, hips, and neck.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 14 Reviews
8.3
9.5
Back pain relief
This vitamin is remarkable! I woke up with terrible back pain, and by the third day of taking it, the pain significantly decreased, disappearing entirely by the tenth day. My sleep has also improved, and the small vitamin dissolves quickly under the tongue with a pleasant fruity taste. It truly works!
Read More
9.5
Anemia treatment
I bought this due to severe anaemia. Switching from 1500mcg to 2500mcg worked wonders, as a blood test confirmed my anaemia was cured. I also suggested it to my aunt for her neuralgia, and she noted a reduction in her back pain!
9.5
Sciatic nerve relief
This was effective for my sciatic nerve pain, which relates to my ongoing problem with back pain. I'm glad I tried it, as it has made a noticeable difference in my condition.
9.5
Pain reduction
This vitamin is excellent! I experienced severe back pain but found relief by the third day of use, with complete recovery after ten days. It dissolves quickly under my tongue and has a sweet, fruity taste. It genuinely works!
9
Nervous system support
Vitamin B12 is essential for the nervous system, aiding myelin synthesis and enhancing signal transmission. After taking it, I felt a surge of energy and vitality, my endurance improved, and I experienced no illnesses or hair loss. It helps keep homocysteine levels in check, protects blood vessel walls, and supports cardiovascular health, which is crucial for alleviating back pain.
Read More
